Pentapeptide compounds and uses related thereto

Details Pentapeptide compounds and uses related thereto Pentapeptide compounds and uses related thereto

C - Chemistry, Metallurgy

07

K

C07K 5/103 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2445875

Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieties, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can serve as a reaction site for joining to a targeting agent, e.g., an antibody, as disclosed.

L'invention concerne des composés pentapeptidiques présentant une activité biologique, par exemple une cytotoxicité. L'invention concerne également des promédicaments présentant des groupes et des fractions pentapeptidiques de ciblage, ainsi que des précurseurs de ces promédicaments, par exemple, des précurseurs présentant une séquence de liaison active qui sert de site de réaction pour la liaison à un agent de ciblage selon l'invention, par exemple à un anticorps.

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