Pentapeptides, processes for their production,...

Details Pentapeptides, processes for their production,... Pentapeptides, processes for their production,...

C - Chemistry, Metallurgy

07

K

530/7.06, 530/5.

C07K 7/06 (2006.01) C07K 14/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1242702

ABSTRACT Pentapeptides of formula I, Image wherein Z1 = H, CH3 or amidino; R1 = H or alkyl and R2 = H or R1 + R2 = -CH2-CH2-; R3 = m- or P-OII or -alkoxy; B = residue of a (D)-.alpha.-amino acid; R4 = H or alkyl; Z2 = optionally substituted phenyl; and E = .beta.-amino alcohol residue (whereby when Z1 = H or CH3, R4 = C3-4-alkyl) as well as their esters and the acid addition salts and complexes of such peptides and esters. Compounds according to the invention have valuable pharmacological, in particular LH- secretion inhibiting activity.

381804

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