C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C07K 14/475 (2006.01) C07K 14/485 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2521393
The present invention relates to an isolated and recombinant fusion peptabody, which binds to a member of the epidermal growth factor receptor useful in inhibiting the growth of certain tumor cells. Also disclosed are, nucleic acids encoding said isolated and recombinant fusion peptabody, kits and pharmaceutical compositions comprising said isolated and recombinant fusion peptabody as an active substance. Finally, a method for the manufacture of said isolated and recombinant fusion peptabody, and its use for the preparation of a medicament for the treatment or prevention of cancer are provided.
La présente invention concerne un peptabody de fusion recombiné et isolé, lequel se fixe sur un membre de la famille des récepteurs du facteur de croissance épidermique et sert à inhiber la croissance de certaines cellules tumorales. Sont également décrits des acides nucléiques codant pour ledit peptabody, des trousses et des compositions pharmaceutiques renfermant ledit peptabody comme substance active. Enfin, l~invention concerne un procédé pour la fabrication dudit peptabody, et son utilisation pour la préparation d~un médicament destiné au traitement ou à la prévention du cancer.
Cloutier Sylvain
Deperthes David
Fattah Omar
Holler Nils
Mach Jean-Pierre
Mbm Intellectual Property Law Llp
Universite de Lausanne
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