A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/704 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2401873
This invention is directed to antineoplastic agents conjugated to enzyme- cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to the use of such conjugated compounds as chemotherapeutic agents in the targeted treatment of cancers.
La présente invention concerne des agents antinéoplastiques conjugués à des peptides pouvant être clivés par des enzymes comprenant la séquence de reconnaissance d'acides aminés d'une peptidase liée à une membrane et/ou sécrétée par une cellule. L'invention traite aussi de l'utilisation desdits composés conjugués tels que des agents chimiothérapeutiques dans le traitement ciblé des cancers.
Albright Charles F.
Combs Andrew P.
Copeland Robert A.
Dimeo Susan V.
Dowling Radine L.
Albright Charles F.
Bristol-Myers Squibb Pharma Company
Combs Andrew P.
Copeland Robert A.
Dimeo Susan V.
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