Peptidase inhibitors

Details Peptidase inhibitors Peptidase inhibitors

C - Chemistry, Metallurgy

07

K

530/5.04, 260/52

C07K 5/04 (2006.01) C07C 271/22 (2006.01) C07C 279/18 (2006.01) C07D 207/16 (2006.01) C07D 209/42 (2006.01) C07D 498/10 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341029

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.

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