Peptidase resistant thrombin receptor peptide ligand

Details Peptidase resistant thrombin receptor peptide ligand Peptidase resistant thrombin receptor peptide ligand

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2165828

A peptide ligand analogue of peptide ligands derived from the trombin-cleaved thrombin receptor site on platelets resists inactivation by aminopeptidase M by substituting the B-amino acid isoserine for the N-terminal serine of the peptide ligand.

Un ligand peptidique analogue de ligands peptidiques dérivés du site récepteur de thrombine détaché de la thrombine sur les plaquettes du sang résiste à l'inactivation par l'aminopeptidase M par remplacement de la sérine N-terminale du ligand peptidique par une isosérine d'acide aminé B.

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