C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/755 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2762020
The present invention provides peptides at least partly derivable from FVIII which are capable of binding to an MHC class II molecule without further antigen processing and being recognised by a factor VIII specific T cell. In particular, the present invention provides a peptide comprising or consisting of the sequence EDNIMVTFRNQASR. The present invention also relates to the use of such a peptide for the prevention or suppression of inhibitor antibody formation in haemophilia A and/or acquired haemophilia.
L'invention porte sur des peptides au moins partiellement dérivés du Facteur VIII et capables de se fixer à une molécule de CMH de classe II sans autre traitement des antigènes, et étant reconnus par une cellule T spécifique du Facteur VIII. L'invention porte en particulier sur un peptide comprenant ou consistant en une séquence EDNIMVTFRNQASR, et également sur l'utilisation d'un tel peptide pour la prévention ou la suppression de la formation d'un anticorps inhibiteur chez les patients atteints d'hémophilie A et/ou d'hémophilie acquise.
Apitope Technology (bristol) Limited
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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