Peptide-aldehydes, process for the preparation thereof and...

C - Chemistry – Metallurgy – 07 – K

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167/103.05, 530/

C07K 5/08 (2006.01) C07K 5/065 (2006.01)

Patent

CA 1261547

A B S T R A C T The invention relates to new peptide-alde- hydes and a process for the preparation thereof, fur- thermore to pharmaceutical compositions containing the same. According to a feature of the present inven- tion there are provided new peptide-aldehyde deriva- tives corresponding to the general formula (I) Image (I) wherein R1 represents hydrogen or C1-6 alkyl group, R2 stands for C1-6 alkyl group, furthermore R1 and R2 are linked to the amino group of the Xxx alpha-amino acid, Xxx represents a D-phenylalanine residue or a D-alpha-amino acid group having in the side chain a C1-4 alkyl group, Pro stands for L-proline residue, Yyy stands for L-, D- or DL-arginine residue and A represents an acid residue. The new peptide-aldehyde derivatives of the invention possess valuable anticoagulant activity.

498306

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