Peptide amidation process

Details Peptide amidation process Peptide amidation process

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) C07K 1/00 (2006.01) C07K 7/06 (2006.01) C07K 7/23 (2006.01) C07K 14/615 (2006.01) C07K 14/655 (2006.01) C07K 14/665 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2485698

The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1- cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cystein is the first amino acid of a palladium cleavage site comprising the sequence cysteine-X2 - X3, wherein X2 is any amino acid, X3 is an amino acid selected from the group consisting of cysteine, histidine, or methionine, and wherein the carboxyl~terminus of the peptide is amidated upon cleavage at the Xl- cysteine sequence.

L'invention concerne un procédé d'amidation d'un peptide souhaité qui consiste à cliver un polypeptide substrat au niveau d'une séquence X¿1?-cystéine, X¿1? étant l'acide aminé situé à l'extrémité carboxylique du peptide et la cystéine étant le premier acide aminé d'un site de clivage du palladium comprenant la séquence cystéine-X2 - X3, X2 étant un acide aminé quelconque, X3 étant un acide aminé sélectionné dans le groupe comprenant cystéine, histidine, ou méthionine, l'extrémité carboxylique du peptide étant amidée après le clivage au niveau de la séquence X¿1?-cystéine.

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