Peptide amides and process for their manufacture

Details Peptide amides and process for their manufacture Peptide amides and process for their manufacture

C - Chemistry, Metallurgy

07

K

530/5

C07K 5/087 (2006.01) C07K 5/107 (2006.01) C07K 14/70 (2006.01)

Patent

CA 1158237

HOE 79/F 225 NEW PEPTIDE AMIDES AND PROCESS FOR THEIR MANUFACTURE Abstract of the disclosure New peptide amides of the formula I H-Tyr-D-Lys(For)-Gly-X (I) wherein For is formyl, X is alkylamino, dehydro-Phe or Phe-alkylamido having up to 6 carbon atoms in the alkyl moiety, which moiety may be sub- stituted by hydroxy and/or phenyl, Phe-cycloalkylamide or Phe-cycloalkylene amide having up to 8 carbon atoms in the cycloalkyl or cyclalky- lene moiety, 1 to 2 CH2 groups being optionally re- placed by -NH-, -O-, -S- or -CO-, Phe-alkylene-cycloalkylamide having from 5 to 6 ring carbon atoms, which amide may be substituted by car- bonamido, N-alkylcarbonamido or alkyl and 1 carbon atom whereof may be replaced by nitrogen, Phe-endo- or exo-norbornylamide or Phe-thiazolamide or Phe-thiazolidine-carboxylic acid amide, which may be sustituted by 1 to 4 methyl groups each, and process for their manufacture are disclosed. These peptide amides are distinguished by an analgetic activity arld suppress the motility of the ileum of the guinea pig.

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