Peptide analogs to proteins of the immunoglobin superfamily

Details Peptide analogs to proteins of the immunoglobin superfamily Peptide analogs to proteins of the immunoglobin superfamily

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/04 (2006.01) A61K 39/42 (2006.01) C07K 7/06 (2006.01) C07K 14/73 (2006.01) C07K 16/42 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2041271

- 34 - PEPTIDE ANALOGS TO PROTEINS OF THE IMMUNOGLOBULIN SUPERFAMILY ABSTRACT OF THE DISCLOSURE A synthetic peptide which is conformationally restricted by means of intramolecular bonding can bind to proteinaceous binding partners. Such binding is not seen in the absence of conformational restriction. The peptides of the invention mimic the biological activi- ties of the proteins of the immunoglobulin superfamily of proteins, providing therapeutic and diagnostic molecules for a broad range of diseases. Methods for molecular modeling to create such peptides employ known structures of other superfamily members.

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