C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2335341
The present invention is directed to novel analogues of PACAP (Pituitary Adenylate Cyclase Activating Polypeptide) as described in the specification, which are agonist of the PACAP receptor and as such are useful in treating cerebrovascular ischemia, male impotence, motor neuron disease, neuropathy, pain, depression, anxiety disorders, brain trauma, memory impairments, dementia, cognitive disorder, central nervous system diseases (such as Parkinson's disease, Alzheimer's disease), migraine, neurodegenerative diseases, ischemic heart disease, myocardial infarction, fibrosis, restenosis, diabetes mellitus, muscle disease, gastric ulcer, stroke, atherosclerosis, hypertension, septic shock, thrombosis, retina disease, cardiovascular disease, renal failure and cardiac failure and the prevention of neuronal cell death in a mammal. This invention is also directed to pharmaceutical compositions useful therefor.
La présente invention concerne des analogues du polypeptide activateur d'adénylate-cyclase hypophysaire ou "PACAP" (Pituitary Adenylate Cyclase Activating Polypeptide) tel que décrit dans la description. Ces analogues, qui sont des agonistes du récepteur de PACAP, conviennent en tant que tels au traitement des troubles et affections telles qu'ischémie vasculaire cérébrale, impuissance masculine, affections neuro-motrices, neuropathies, douleur, dépression, troubles de l'anxiété, traumatisme cérébral, troubles de la mémoire, démence, troubles cognitifs, affections du système nerveux central (maladie de Parkinson et maladie d'Alzheimer), migraine, affections neurodégénératives, cardiopathies ischémiques, infarctus du myocarde, fibrose, resténose, diabète sucré, affections musculaires, ulcère de l'estomac, apoplexie, athérosclérose, hypertension, choc septique, thrombose, rétinopathie, affections cardio-vasculaires, insuffisance rénale et insuffisance cardiaque, ainsi que la prévention de la mort cellulaire du neurone chez un mammifère. L'invention concerne également des compositions pharmaceutiques convenant à cet effet.
Ipsen Pharma S.a.s
Smart & Biggar
Societe de Conseils de Recherches Et D'applications Scientifique
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