A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07K 7/00 (2006.01) C07K 7/04 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C12N 9/00 (2006.01) C12N 9/88 (2006.01) A61K 38/11 (2006.01)
Patent
CA 2376250
The present invention relates to peptides and peptide analogues designed from a human pancreatic islet beta cell autoantigen GAD65. In particular, it relates to antagonistic peptides and peptide analogues that antagonize autoimmune T cell activation in response to GAD65. The invention also relates to methods of using such peptides and peptide analogues for the treatment and prevention of type I diabetes or pre-diabetes or recurring autoimmunity after islet cell transplantation.
L'invention concerne des peptides et des analogues peptidiques conçus à partir d'un auto-antigène GAD65 de la cellule humaine bêta des îlots pancréatiques et elle concerne notamment des peptides antagonistes et des analogues peptidiques qui antagonisent l'activation des lymphocytes T auto-immuns en réponse à GAD65. L'invention concerne encore des méthodes d'utilisation de tels peptides et analogues peptidiques dans le traitement et la prévention du diabète ou pré-diabète de type I, ou dans la récurrence de maladies auto-immunes après transplantation d'îlots.
Masewicz Susan
Nepom Barbara S.
Nepom Gerald T.
Benaroya Research Institute At Virginia Mason
Fetherstonhaugh & Co.
Virginia Mason Research Center
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