Peptide and polypeptide inhibitors of complement c1s

Details Peptide and polypeptide inhibitors of complement c1s Peptide and polypeptide inhibitors of complement c1s

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/815 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2413830

The complement system plays an important role in providing resistance to infections and in the pathogenesis of tissue injury. Yet an inappropriate activation of complement can result in a variety of disorders. The present invention provides C1s catalytic site-directed moieties, C1s exosite binding moieties, and bivalent polypeptide inhibitors comprising such moieties, which can be used to treat conditions characterized by inappropriate complement activation.

La présente invention concerne un système qui joue un rôle majeur dans la résistance aux infections et dans la pathogenèse des lésions tissulaires. L'activation appropriée d'un complément peut entraîner divers troubles. La présente invention se rapporte à des fractions catalytiques C1s dirigées sur site, des fractions C1s de liaison à l'exo-site, et des inhibiteurs polypeptidiques bivalents contenant de telles fractions, qui peuvent être utilisés pour traiter des états caractérisés par une activation inappropriée du complément.

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