C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2738744
The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor a(TNF.alpha.) induction and the expression of IL-8 and IL-6 by the IL-15 receptor .alpha. subunit (IL-15R.alpha.), all these effects mediated by the binding of the peptide to the IL-15R.alpha.. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15R.alpha. is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer.
La présente invention concerne le domaine de la pharmacologie moléculaire, et notamment un peptide dérivé de la séquence de l'interleukine-15 (IL-15), optimisé pour inhiber l'activité biologique de cette molécule. Dans la présente invention, on démontre que ce peptide, lorsqu'il s'unit à la sous-unité alpha du récepteur (IL-15a), inhibe la prolifération de cellules T induite par l'IL-15, l'induction de facteur de nécrose tumorale a (TNFa) par l'IL-15, et l'expression de l'IL-8 et de l'IL-6 par l'IL-15Ra. L'invention concerne également l'utilisation dudit peptide pour traiter des pathologies dans lesquelles l'expression anormale de l'IL-15 ou de l'IL-15Ra est associée au développement d'une maladie, telle que l'arthrite rhumatoïde (AR) et le cancer de la prostate.
Garay Perez Hilda Elisa
Geronimo Perez Haydee
Guillen Nieto Gerardo Enrique
Reyes Acosta Osvaldo
Rodriguez Alvarez Yunier
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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