C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.06, 530/3.
C07K 7/06 (2006.01) C07K 7/22 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1291592
PEPTIDE ANTAGONISTS OF NEUROKININ B Abstract Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptides are of the following formula A1-D-Pro2-His3-D4-Phe5-D-Trp6-Val7-D-Trp8-Leu9-Nle10-NH2 (I) wherein A1 and D4 are Asp or D-Asp amino acids. Also described is an opthalmic solution to treat pain or inflammation and an HPLC separation method using piperidine.
519316
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
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