Peptide antagonists of neurokinin b

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

530/7.06, 530/3.

C07K 7/06 (2006.01) C07K 7/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1291592

PEPTIDE ANTAGONISTS OF NEUROKININ B Abstract Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptides are of the following formula A1-D-Pro2-His3-D4-Phe5-D-Trp6-Val7-D-Trp8-Leu9-Nle10-NH2 (I) wherein A1 and D4 are Asp or D-Asp amino acids. Also described is an opthalmic solution to treat pain or inflammation and an HPLC separation method using piperidine.

519316

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