C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2313390
The present invention provides isolated polypeptides having VEGF antagonist activity, pharmaceutical compositions and methods of treatment. The polypeptides of the invention include polypeptides comprising a portion of SEQ ID NO:1 having VEGF antagonist activity, polypeptides comprising SEQ ID NO:2 or a portion thereof having VEGF antagonist activity, and a polypeptide having the structure of formula (I), set forth above. The present invention further includes analogs and derivatives of these polypeptides having VEGF antagonist activity.
L'invention porte sur des polypeptides isolés à activité d'antagonistes du VEGF, sur des préparations pharmaceutiques et des méthodes de traitement associées. Lesdits polypeptides en comprennent certains qui comportent une partie de la SEQ ID NO:1 à activité d'antagonistes du VEGF, certains autres qui comportent la SEQ ID NO:2 ou l'une de ses parties à activité d'antagonistes du VEGF, ainsi qu'un polypeptide présentant la structure de la formule (I) donnée ci-dessus. L'invention porte en outre sur des analogues et dérivés des susdits polypeptides à activité d'antagonistes du VEGF.
Klagsbrun Michael
Soker Shay
Children's Medical Center Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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