Peptide antibodies and their use in detecting oncogene products

Details Peptide antibodies and their use in detecting oncogene products Peptide antibodies and their use in detecting oncogene products

C - Chemistry, Metallurgy

07

K

167/139, 530/15,

C07K 7/08 (2006.01) A61K 33/44 (2006.01) C07K 14/82 (2006.01) G01N 33/531 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1265649

Abstract of the Disclosure Antibodies exhibit specificity toward single amino acid differences between proteins. These antibodies may be produced by synthesizing a peptide of the appropriate amino acid sequence contained in the protein, immunizing a host with the peptide, and extracting sera from the host to obtain the antibodies. The antibodies and the desired protein are then immunoprecipiated under conditions of partial denaturation to expose the epitope of the protein. The antibodies may be used for diagnostic or therapeutic purposes.

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