Peptide-based gemini compounds

Details Peptide-based gemini compounds Peptide-based gemini compounds

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 5/09 (2006.01) C07K 5/11 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2312941

New peptide-based gemini compounds comprising two linked chains (a) each chain having: (1) a positively charged hydrophilic head, Q1 or Q2, formed from one or more amino acids and/or amines, (2) a central portion, P1 or P2, having a polypeptide backbone, and (3) a hydrophobic tail, R1 or R2, the central sections of each chain being linked together by bridge Y through residues in P1 and P2, are disclosed. Methods for their preparation and uses are also disclosed. Such uses include transfection of polynucleotides into cells in vivo and in vitro.

Nouveaux composés doubles à base de peptides, comprenant deux chaînes liées (a) comportant chacune: (1) une tête hydrophile à charge positive, Q?1¿ ou Q?2¿, formée à partir d'au moins un acide aminé et/ou d'au moins une amine; (2) une partie centrale, P?1¿ ou P?2¿, ayant un squelette polypeptidique; et (3) une queue hydrophobe, R?1¿ ou R?2¿, les sections centrales de chaque chaîne étant liées entre elles par un pont Y, par l'intermédiaire des résidus P?1¿ et P?2¿. Des procédés de préparation et d'utilisation desdits composés sont également décrits. Les utilisations comprennent la transfection de polynucléotides dans des cellules, in vivo et in vitro.

Affiliated with

Also associated with

Rating

Peptide-based gemini compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide-based gemini compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide-based gemini compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1614627