Peptide based inhibition of capcna protein-protein...

Details Peptide based inhibition of capcna protein-protein... Peptide based inhibition of capcna protein-protein...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2638866

Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (caPCNA, also known as csPCNA) or from nmPCNA-interacting proteins interfere with intracellular protein-protein interaction, thereby causing a reduction in the proliferative potential of cancer. These peptides serve as therapeutic compositions to reduce the proliferation of cancer cells and also augment existing chemotherapeutic methods.

L'invention concerne des peptides dérivés d'isoforme spécifique de cancer d'antigène nucléaire de cellules proliférantes (caPCNA, aussi connu comme csPCNA), ou de protéines interagissant avec nmPCNA, qui interférent avec une interaction protéine-protéine intracellulaire, en causant ainsi une réduction du potentiel prolifératif d'une cancer. Ces peptides servent de compositions thérapeutiques pour réduire la prolifération de cellules cancéreuses et aussi pour augmenter des méthodes chimiothérapeutiques existantes.

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