C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2500895
The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical of prophylactical treatment of atherosclerosis by means of passive immunization, as well as method for preparing such antibodies, and a method for treating a mammal, preferably a human using such an antibody to provide for passive immunization.
La présente invention concerne l'immunisation passive pour le traitement ou la prévention de l'athérosclérose, reposant sur l'utilisation d'un anticorps humain isolé dirigé contre au moins un fragment oxydé d'apolipoprotéine B dans la fabrication d'une composition pharmaceutique pour le traitement thérapeutique ou prophylactique de l'athérosclérose à l'aide de l'immunisation passive. Elle concerne également une méthode de préparation de ces anticorps et un procédé de traitement d'un mammifère, de préférence un être humain, à l'aide d'un anticorps susmentionné pour conférer une immunisation passive.
Bengtsson Jenny
Carlsson Roland
Nilsson Jan
Strandberg Leif
Bioinvent International Ab
Forskarpatent I. Syd Ab
Mccarthy Tetrault Llp
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