Peptide boronic acid inhibitors of trypsin-like proteases

Details Peptide boronic acid inhibitors of trypsin-like proteases Peptide boronic acid inhibitors of trypsin-like proteases

C - Chemistry, Metallurgy

07

K

530/5.04, 530/7.

C07K 5/04 (2006.01) C07F 5/02 (2006.01) C07K 7/04 (2006.01)

Patent

CA 1333208

Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.

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