Peptide, bronchodilator and blood flow ameliorant

Details Peptide, bronchodilator and blood flow ameliorant Peptide, bronchodilator and blood flow ameliorant

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/22 (2006.01) A61K 38/26 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2196308

The present invention relates to a peptide represented by the general formula (1): H-His-Ser-Asp-A-B-Phe-Thr-Asp-C-Tyr-D-Arg-E-Arg-F-Gln-G-Ala-Val-I-J- Tyr-Leu-K-L-M-Leu-N (1) wherein A is Ala or Gly; B is Ile or Val; C is Asn or Ser; D is Thr or Ser; E is Leu or Tyr; each of F, I and J is Lys or Arg, and at least one of F, I and J is Arg; G is Met, Leu or Nle; K is Asn or Ala; L is Ser or Ala; M is Ile or Val; and N is -NH2 or Asn-NH2, excluding the combination where A is Ala, B is Val, C is Asn, D is Thr, E is Leu, K is Asn, L is Ser, M is Ile, and N is Asn-NH2, and pharmaceutically acceptable salts thereof, as well as to a bronchus-expanding agent or a blood-flow-improving agent comprising said peptide or a pharmaceutically acceptable salt thereof as an active ingredient.

La présente invention concerne des peptides représentés par la formule générale (1): H-His-Ser-Asp-A-B-Phe-Thr-Asp-C-Tyr-D-Arg-E-Arg-F-Gln-G-Ala-Val-I-J-Tyr-Leu-K-L-M-Leu-N, ou certains de leurs sels admis en pharmacologie. L'invention concerne également un bronchodilatateur ou un agent facilitant l'écoulement sanguin et dont le principe actif est un tel peptide. Dans cette formule générale (1), A représente Ala ou Gly, B représente Ile ou Val, C représente Asn ou Ser, D représente Thr ou Ser, E représente Leu ou Tyr, F, I et J représentent chacun Lys ou Arg, à condition qu'au moins l'un d'entre eux représente Arg; G représente Met, Leu ou Nle, K représente Asn ou Ala, L représente Ser ou Ala, M représente Ile ou Val et N représente -NH2 ou Asn-NH2, à l'exception du cas où, simultanément A est Ala, où B est Val, C est Asn, D est Thr, E est Leu, K est Asn, L est Ser, M est Ile et N est Asn-NH2.

Affiliated with

Also associated with

Rating

Peptide, bronchodilator and blood flow ameliorant does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide, bronchodilator and blood flow ameliorant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide, bronchodilator and blood flow ameliorant will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1623213