Peptide-carbohydrate conjugates generating t-cell immunity

Details Peptide-carbohydrate conjugates generating t-cell immunity Peptide-carbohydrate conjugates generating t-cell immunity

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 35/18 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07H 15/04 (2006.01) C07H 15/18 (2006.01) C07K 14/005 (2006.01) C07K 14/11 (2006.01)

Patent

CA 2134097

2134097 9321948 PCTABS00027 The present invention relates to a novel class of biologically active compounds, to processes for their production and to their use in therapy. More particularly the invention provides immunogenic conjugates useful for generating T cell immunity against tumor-associated carbohydrate structures or against carbohydrate structures expressed on infectious agents and/or infected host cells. The said immunogenic conjugate comprises (i) a peptide component capable of binding an MHC class I molecule; and (ii) a carbohydrate component having the immunogenic specificity of said carbohydrate structure.

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