Peptide-chelator conjugates

Details Peptide-chelator conjugates Peptide-chelator conjugates

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2182670

Peptide-chelator conjugates are provided that when labelled with a traceable metal are useful for diagnostic imaging of sites of inflammation. The peptide component is an antagonist of the naturally occurring tetrapeptide tuftsin while the chelator component serves as a labelling site for metals, in particular radionuclide metals such as technetium-99m.

On décrit des produits de conjugaison peptides-chélates qui, une fois marqués avec un métal détectable, servent à l'imagerie diagnostique des sites d'inflammation. Le composant peptidique est un antagoniste d'un tétrapeptide naturel, la tuftsine, et le composant chélateur sert de site de marquage pour les métaux et, en particulier, pour les radionucléides tels que le technétium 99m.

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