C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/44 (2006.01) C07K 16/00 (2006.01) A61K 38/11 (2006.01)
Patent
CA 2329754
The invention provides peptides comprising a sequence homologous to a portion of the third constant domain of the epsilon heavy chain of IgE, covalently linked to either (1) a carrier protein, or (2) a helper T cell epitope, and optionally to other immunostimulatory sequences as well. The invention provides for the use of such peptides as immunogens to elicit the production in mammals of high titer polyclonal antibodies, which are specific to a target effector site on the epsilon heavy chain of IgE. The peptides are expected to be useful in pharmaceutical compositions, to provide an immunotherapy for IgE- mediated allergic diseases.
L'invention concerne des peptides, comprenant un homologue de séquence vers une partie du troisième domaine constant de la chaîne lourde epsilon de IgE, relié de manière covalente (1) à une protéine de support, ou (2) à un épitope de lymphocyte T auxiliaire, et éventuellement à d'autres séquences immunostimulatoires. L'invention concerne également l'utilisation de ces peptides comme immunogènes permettant de produire des anticorps polyclonaux de titre élevé chez les mammifères, spécifiques à un site effecteur cible sur la chaîne lourde epsilon de IgE. Ces peptides sont utiles dans des compositions phamaceutiques qui fournissent une immunothérapie contre des maladies allergiques à médiation IgE.
Walfield Alan M.
Wang Chang Yi
Mcfadden Fincham
United Biomedical Inc.
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