Peptide compositions with growth factor-like activity

Details Peptide compositions with growth factor-like activity Peptide compositions with growth factor-like activity

C - Chemistry, Metallurgy

07

K

C07K 14/495 (2006.01) A61K 38/08 (2006.01) A61K 38/18 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61L 27/22 (2006.01) C07K 7/06 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2218161

A peptide has been synthesized with the sequence ANVAENA (SEQ ID NO:1). This peptide, designated "cytomodulin", is able to mimic a broad range of activities of TGF-.beta.1 in various cell types. Compositions for applications such as tissue repair are provided that comprise a biocompatible matrix having cytomodulin admixed with or carried by the matrix.

La présente invention concerne un peptide synthétisé avec la séquence ANVAENA (SEQ ID NO:1). Ce peptide, dénommé "cytomoduline", est capable d'imiter une vaste gamme d'activités de TGF- beta 1 dans différents types de cellules. L'invention concerne également des compositions destinées à des applications telles que la réparation tissulaire, et qui intègrent une matrice biocompatible additionnée de cytomoduline ou de la cytomoduline portée par la matrice.

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