Peptide compounds and their use as protease substrates

Details Peptide compounds and their use as protease substrates Peptide compounds and their use as protease substrates

C - Chemistry, Metallurgy

12

N

C12N 9/52 (2006.01) C07K 7/06 (2006.01) C07K 14/78 (2006.01) C12N 1/00 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2485437

This invention is directed generally to peptide compounds and salts, and particularly to peptide compounds and salts that are useful as protease substrates, such as matrix metalloprotease (~MMP~) substrates. This invention also is directed to methods for making such compounds and salts, as well as amino acids that may, for example, be used in such methods. This invention is further directed to methods for using such compounds and salts to, for example, evaluate the effectiveness of potential protease inhibitors and to detect or monitor a disease associated with protease activity.

Cette invention se rapporte de façon générale à des composés peptidiques et à des sels et, en particulier, à des composés peptidiques et à des sels qui sont utiles comme substrats de protéases, par exemple comme substrats de métalloprotéases matricielles (MMP). Cette invention concerne également des procédés pour produire ces composés et ces sels, ainsi que des acides aminés qui peuvent par exemple être utilisés dans ces procédés. Cette invention concerne en outre des procédés utilisant ces composés et ces sels par exemple pour évaluer l'efficacité d'inhibiteurs de protéases potentiels et pour détecter ou surveiller une maladie associée à l'activité des protéases.

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