C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.04, 167/10
C07K 5/04 (2006.01) C07K 5/078 (2006.01) C07K 5/083 (2006.01)
Patent
CA 1329444
ABSTRACT There are described compounds of the formula: R1-A-D-Trp(R2)-Phe-R3 wherein R1 is hydrogen or an amino protective group, R2 is hydrogen, an amino protective group, carbamoyl(lower)alkyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, R3 is ar(lower)alkyl, a group of the formula: Image wherein R4 and R5 are each hydrogen, aryl or lower alkyl which may have suitable substituent(s), or R4 and R5 are linked together to form benzene-condensed lower alkylene, or a group of the formula : -OR6 wherein R6 is hydrogen, aryl or lower alkyl which may have suitable substituent(s), and A is a single bond or one or two amino acid(s) residue, provided that when A is one amino acid residue of -D-Trp-, then R4 is not hydrogen, and pharmaceutically acceptable salts thereof. These compounds possess pharmaceutical activity, for example they can be used as tachykinin antagonism or the like. A method for the treatment and the prevention of asthma, the process for pre- paring the compounds as well as pharmaceutical preparations containing them are also described.
593831
Hagiwara Daijiro
Matsuo Masaaki
Miyake Hiroshi
Fujisawa Pharmaceutical Co. Ltd.
Swabey Ogilvy Renault
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