Peptide compounds useful for modulating fgf receptor activity

Details Peptide compounds useful for modulating fgf receptor activity Peptide compounds useful for modulating fgf receptor activity

C - Chemistry, Metallurgy

07

K

C07K 14/50 (2006.01) A61K 38/18 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2270871

This invention provides peptide compounds that bind to either of fibroblast growth factor (FGF) or a fibroblast growth factor receptor (FGFR) and, accordingly, are useful for modulating FGFR activity. Preferably, the FGFR is FGFR2-IIIC. Preferably, the FGF is basic FGF. Preferably the peptide compound comprises an amino acid sequence (Y/F)-(L/F/I)-(R/D/E/S/Y/G)-(Q/L/Y)-Y- (M/L/K/R)-(L/M/D/E/N/S)-(R/L/S/T)-(L/F/M/V) (SEQ ID NO:1). The invention further comprises pharmaceutical compositions comprising the peptide compounds of the invention and a pharmaceutically acceptable carrier. The invention still further provides methods of modulating FGFR activity using the peptide compounds of the invention.

Cette invention concerne des composés de peptides qui se lient soit à un facteur de croissance des fibroblastes (FGF) soit à un récepteur du facteur de croissance des fibroblastes (FGFR) et qui conviennent par conséquent pour moduler l'activité du FGFR. Le FGFRR est de préférence un FGFR2-IIIC et le FGF et, quant à lui, de préférence le FGF basique. Le composé peptidique comprend de préférence une séquence d'acides aminés telle que: (Y/F)-(L/F/I)-(R/D/E/S/Y/G)-(Q/L/Y)-Y-(M/L/K/R)-(L/M/D/E/N/S)-(R/L/S/T)-(L/F/M/V) (SEQ ID NO: 1). Cette invention concerne également des compositions pharmaceutiques contenant ces composés peptidiques et un support pharmaceutiquement acceptable. L'invention concerne enfin des procédés de modulation de l'activité du FGFR dans lesquels on utilise lesdits composés peptidiques.

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