A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 25/04 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2617449
The present invention provides a method of improving the oral delivery of a parent peptide, comprising the step of linking the parent peptide to an added peptide to form a conjugate which has greater oral bioavailability than the parent molecule alone, the added peptide comprising a balance of hydrophobic and hydrophilic residues as defined herein. Conjugates for use in the method are also provided, as are pharmaceutical compositions comprising the conjugate and methods of treatment using the conjugate or pharmaceutical composition.
L'invention porte sur un procédé destiné à améliorer l'administration orale d'un peptide parent, et qui consiste à lier le peptide parent à un peptide ajouté pour former un conjugué qui possède une biodisponibilité orale plus importante que la molécule parent seule, le peptide ajouté renfermant des résidus hydrophobes et hydrophiles répartis de manière homogène. L'invention décrit également des conjugués utilisés selon le procédé, ainsi que des compositions pharmaceutiques renfermant le conjugué et des méthodes de traitement utilisant le conjugué ou la composition pharmaceutique.
Metabolic Pharmaceuticals Limited
Ridout & Maybee Llp
LandOfFree
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