Peptide conjugates derived from thymic hormones, their use...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/66 (2006.01) A61K 38/04 (2006.01) A61K 38/22 (2006.01) A61K 38/32 (2006.01) A61K 47/48 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2237995

The invention relates to peptide conjugates comprising a sequence of at least 3 amino acids derived from a thymic hormone selected amongst thymuline and thymopoïetine, the amino acids being independently in the form D, L or DL, said sequence being chemically or physically conjugated with at least one compound selected amongst monocarboxylic acids having the general formula (I): HOOC-R, as well as alcohol, aldehyde or amide derivatives, the dicarboxylic acids having the general formula (II): HOOC-R¿1?-COOH. The invention also relates to the use of such conjugates as medicaments, and pharmaceutical or cosmetological compositions containing them.

L'invention concerne des conjugués peptidiques comprenant une séquence d'au moins 3 acides aminés dérivés d'une hormone thymique choisie parmi la thymuline et la thymopoïétine, les acides aminés pouvant être indépendamment sous forme D, L ou DL, ladite séquence étant conjuguée chimiquement ou physiquement avec au moins un composé sélectionné parmi: les acides monocarboxyliques de la formule générale (I): HOOC-R, ainsi que les dérivés alcool, aldéhyde ou amide; les acides dicarboxyliques de la formule générale (II): HOOC-R1-COOH. Elle concerne également leur utilisation à titre de médicament et des compositions pharmaceutiques ou cosmétologiques les contenant.

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