C - Chemistry – Metallurgy – 11 – D
Patent
C - Chemistry, Metallurgy
11
D
C11D 3/33 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2376650
The present invention provides a novel class of detergents referred to herein as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic .alpha.-helical peptide having a hydrophobic or neutral face and a hydrophilic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof. Image
La présente invention concerne une nouvelle classe de détergents, en l'occurrence des détergents lipopeptides. Ces détergents lipopeptides comprennent un peptide alpha -hélicoïdal amphipathique portant une face hydrophobe ou neutre et une face hydrophile. A chaque extrémité de ce peptide se trouve une queue hydrocarbure aliphatique reliée au peptide de façon qu'il s'associe avec la face hydrophobe ou neutre du peptide. De tels détergents lipopeptides conviennent à la stabilisation de protéines membranaires en l'absence d'un bi-couche phospholipide de façon à préserver la conformation d'origine et à en permettre la cristallisation ultérieure.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Health Network
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