Peptide deformylase activated prodrugs

Details Peptide deformylase activated prodrugs Peptide deformylase activated prodrugs

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 47/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2447470

This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformy- lase by contacting themicroorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gra m-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. Catarrhalis,E. coli, E. faecalis, H. influenzae and P aeruginosa. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symtoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.

L'invention concerne une méthode d'inhibition de la croissance d'un microorganisme exprimant la peptide déformylase, consistant à mettre en contact le microorganisme avec une quantité efficace du composé décrit par l'invention. Ladite méthode inhibe la croissance d'un microorganisme gram-positif et gram-négatif, par exemple S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. Catarrhalis,E. coli, E. faecalis, H. influenzae et P. aeruginosa. Cette méthode peut être mise en oeuvre in vitro, ex vivo et in vivo. L'invention concerne, de plus, une méthode visant à soulager les symptômes d'une infection par un microorganisme exprimant la peptide déformylase chez un sujet en administrant ou délivrant au sujet une quantité efficace du composé décrit ci-dessus.

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