A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 35/74 (2006.01) A61K 39/02 (2006.01) A61K 47/42 (2006.01) A61K 49/00 (2006.01) C07K 5/06 (2006.01) C12Q 1/18 (2006.01)
Patent
CA 2482029
This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, and E. cloacae. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
L'invention concerne un procédé permettant d'inhiber la croissance d'un micro-organisme qui exprime la peptide déformylase par mise en contact de ce micro-organisme avec une dose efficace d'un composé décrit dans l'invention. Ce procédé inhibe la croissance de micro-organismes gram-positifs et gram-négatifs, de type S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, et E. cloacae. Ledit procédé peut être mis en oeuvre in vitro, ex vivo et in vivo. L'invention concerne en outre un procédé permettant de soulager les symptômes d'une infection par un micro-organisme exprimant la peptide déformylase chez un sujet par administration ou distribution à ce dernier d'une dose efficace du composé précédemment mentionné.
Doppalapudi Venkata Ramana
Sergeeva Maria V.
Borden Ladner Gervais Llp
Celmed Oncology (usa) Inc.
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