C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2658801
The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from Mycobacterium tuberculosis. The use of this Antisense-oligonucleotide on mycobacterial culture inhibits the production of the peptide deformylase enzyme by hybridizing within the region, which is found to be responsible for maintaining stability as well as retaining the functionality of the enzyme and thus in turn affecting the growth of the cells. This invention also establishes the essentiality of the peptide deformylase enzyme in mycobacteria and claims it as a drug target in this microorganism.
La présente invention concerne la mise au point de l'oligonucléotide antisens complémentaire à la région spécifique du gène peptide déformylase provenant de Mycobacterium tuberculosis. L'utilisation de cet oligonucléotide antisens sur une culture mycobactérienne inhibe la production de l'enzyme peptide déformylase par une hybridation à l'intérieur de la région qui est trouvée être responsable de maintenir la stabilité ainsi que de conserver la fonctionnalité de l'enzyme, et ainsi, à son tour, d'affecter la croissance des cellules. Cette invention établit également le caractère essentiel de l'enzyme peptide déformylase dans les mycobactéries et la revendique en tant que médicament cible dans ce microorganisme.
Chakraborti Pradip Kumar
Saxena Rahul
Blake Cassels & Graydon Llp
Council Of Scientific & Industrial Research
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