Peptide deformylase inhibitors

Details Peptide deformylase inhibitors Peptide deformylase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61K 31/5383 (2006.01) A61P 31/04 (2006.01) C07D 405/12 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2705246

The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hy- drazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I), wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

La présente invention concerne certains dérivés de {2-(alkyl)-3-[2- (5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide, des compositions les contenant, l'utilisation de ces composés pour inhiber l'activité de la peptide déformylase (PDF) bactérienne et pour traiter des infections bactériennes. Spécifiquement, l'invention concerne des composés de formule (I), dans laquelle R1, R2 et R3 sont tels que définis dans la présente, ainsi que leurs sels pharmaceutiquement acceptables. Les composés de l'invention sont des inhibiteurs de la peptide déformylase bactérienne et ils peuvent être utiles dans le traitement d'infections bactériennes.

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