Peptide derivatives

Details Peptide derivatives Peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 31/195 (2006.01) A61K 38/08 (2006.01) C07C 229/06 (2006.01) C07C 229/08 (2006.01) C07C 237/08 (2006.01) C07C 271/22 (2006.01) C07K 7/02 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2252417

The invention concerns pharmaceutically useful peptide derivatives of the formula (I), P-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-Q, in which P, AA1, AA2, AA3, AA4, AA5, AA6, AA7, AA8, and Q have the various meanings defined herein and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.

L'invention concerne des dérivés de peptides pharmaceutiquement utiles ayant la formule (I), P-AA?1¿-AA?2¿-AA?3¿-AA?4¿-AA?5¿-AA?6¿-AA?7¿-AA?8¿-Q, dans laquelle P-AA?1¿, AA?2¿, AA?3¿, AA?4¿, AA?5¿, AA?6¿, AA?7¿, AA?8¿ et Q ont les différentes significations définies dans ladite formule, leurs sels pharmaceutiquement acceptables et les compositions pharmaceutiques contenant lesdits sels. Les nouveaux dérivés de peptides sont utiles dans le traitement de maladies auto-immunes ou inflammatoires dues aux lymphocytes dépendant du CMH de classe II, telles que la polyarthrite rhumatoïde. L'invention concerne en outre des procédés de fabrication des nouveaux dérivés de peptides et l'utilisation de leurs composés dans un traitement médical.

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