Peptide derivatives

Details Peptide derivatives Peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) C07K 5/02 (2006.01) C07K 5/087 (2006.01) C07K 5/097 (2006.01) C07K 5/107 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2231220

Compounds represented by the following general formula and salts thereof: HN=C(R1)-X-Y-NH-CH(R2)-CO-Q, wherein R1 represents amino, etc.; R2 represents substituted benzyl, etc.; X represents a Pro residue, a substituted tyrosine residue, etc.; Y represents an alanine residue, etc.; and Q represents N- methyl-.beta.-alanine, etc. Because of having an analgetic effect, the compounds are usable in the treatment of cancer pain, etc.

On décrit des composés et leurs sels représentés par la formule générale HN=C(R?1¿)-X-Y-NH-CH(R?2¿)-CO-Q, où R?1¿ représente amino, etc.; R?2¿ représente benzyle substitué, etc.; X représente un résidu Pro, un résidu tyrosine substitué, etc.; Y représente un résidu alanine, etc.; et Q représente N-méthyle-.beta.-alanine, etc. Grâce à leurs effets analgésiques, ces composés s'utilisent pour traiter des douleurs dues au cancer, etc.

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