Peptide derivatives

Details Peptide derivatives Peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/083 (2006.01) C07K 5/107 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2242809

The invention concerns pharmaceutically useful peptide derivatives of the formula (I): P-R1-R2-R3-R4, in which P, R1, R2, R3, and R4 have the various meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.

Cette invention concerne des dérivés peptidiques, pharmaceutiquement utiles, de formule (I): P-R?1¿-R?2¿-R?3¿-R?4¿, dans laquelle P, R?1¿, R?2¿, R?3¿ et R?4¿ ont les diverses significations données dans la description, leurs sels pharmaceutiquement acceptables ainsi que des compositions pharmaceutiques les contenant. Ces nouveaux dérivés peptidiques sont utiles dans le traitement des maladies inflammatoires ou auto-immunes induites par des cellules T dépendant du complexe majeur d'histocompatibilité (CMH) de classe II, telles que l'arthrite rhumatoïde. Cette invention concerne également des procédés de production de ces nouveaux dérivés peptidiques ainsi que l'utilisation de ces composés en thérapie.

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