Peptide derivatives

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/107 (2006.01) C07K 5/023 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2185212

A peptide derivative having analgesic activity represented by the following formula: Image wherein Q represents D-Arg or L-Arg; and X represents for example NR6-CHR7R8. Typical compounds include H2NC(NH)-Tyr-D-Arg-Phe- NHCH2CH2COOH and H2NC(NH)-Tyr-D-Arg-Phe-NHCH2CH2CONH2.

Dérivé peptidique analgésique représenté par la formule générale (I) (dans laquelle Q représente D-Arg ou L-Arg; et X représente NR<6>-CHR<7>R<8>, etc.). Des exemples représentatifs sont H2NC(NH)-Tyr-D-Arg-Phe-NHCH2CH2COOH et H2NC(NH)-Tyr-D-Arg-Phe-NHCH2CH2CONH2.

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