Peptide derivatives

Details Peptide derivatives Peptide derivatives

C - Chemistry, Metallurgy

07

K

167/205, 530/7,

C07K 5/08 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1247089

- 1 - Novel peptide derivatives Abstract The invention relates to lipopeptides of the formula I, (I) Image * = R ** = R or S *** = R in which each of R?a and R?, independently of the other, repre- sents an aliphatic or aliphatic-cycloaliphatic hydrocarbon radical having from 7 to 21 carbon atoms that is optionally substituted by oxygen functions, or one of the radicals R?-CO- and R?-CO- represents hydrogen and the other of the radicals R?-Co- and R?-Co- represents an acyl radical, wherein R? and R? have the meanings given above, - 2 - R2 represents an aliphatic or aliphatic-cyclo- aliphatic hydrocarbon radical having from 1 to 21 carbon atoms that is optionally substi- tuted by oxygen functions, n = O or 1, As° represents a radical of the formula -O-Kw-CO- or -NH-Kw-CO- wherein Kw represents an aliphatic hydrocarbon radical having a maximum of 12 carbon atoms, As1 represents a D- or L-.alpha.-amino acid, each of Z1 and Z2, independently of the other, repre- sents hydroxy or the N-terminal radical of a D- or L-.alpha.-aminocarboxylic acid, of an amino- lower alkanesulphonic acid or of a peptide having a maximum of 6 amino acids from the group consisting of D- or L-.alpha.-aminocarboxylic acids and amino-lower alkanesulphonic acids, and Z3 represents hydrogen or -CO-Z4 wherein Z4 represents hydroxy or the N-terminal radical of a D- or L-.alpha.-amino acid, of an amino-lower alkanesulphonic acid or of a peptide having a maximum of 6 amino acids from the group consisting of D- or L-.alpha.-aminocarboxylic acids and amino-lower alkanesulphonic acids, and the amides and esters of such compounds that contain carboxy groups. The novel lipopeptides have an immunity- stimulating action.

445858

Affiliated with

Also associated with

Rating

Peptide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1201958