Peptide derivatives and their application, in particular in...

Details Peptide derivatives and their application, in particular in... Peptide derivatives and their application, in particular in...

C - Chemistry, Metallurgy

07

K

150/3, 530/7.06,

C07K 7/06 (2006.01) C07K 5/10 (2006.01) C07K 5/11 (2006.01) C07K 14/75 (2006.01) C12Q 1/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1311583

Novel peptide derivatives and their application, in particular in therapy ABSTRACT OF THE TECHNICAL CONTENT OF THE INVENTION The subject of the invention is peptide derivatives corresponding to formula X1 - X2 - Gly - Asp - X3 - X4 (I) . in which: X1 represents a hydrogen atom, a N-protecting group, an amino acid residue or a N-protected amino acid residue, X2 represents a residue of L-Arg or D-Arg, L-Orn or D-Orn, N-aminocarbonyl -L-Orn or N-aminocarbonyl-D-Orn, or L-Lys, or D-Lys, X3 represents a residue of L-Trp, D-Trp, L-Leu, D-Leu, L-Ile, D-Ile, L-Phe, D-Phe or a chain of 2 or 3 of these residues, and X4 represents a -OH group, -NH2 group, -OR1 group in which R1 represents an alkyl radical of Cl to C4, a NHR2 group in which R2 represents an alkyl radical of Cl to C4, or an amino acid residue. These derivatives are useful in therapy on account of their platelet aggregation inhibiting activity.

554217

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