C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/22 (2006.01) A61K 31/27 (2006.01) A61K 31/495 (2006.01) A61K 38/04 (2006.01) A61P 1/02 (2006.01) C07D 295/185 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) C07K 5/093 (2006.01)
Patent
CA 2396678
The present invention provides a peptide derivative of formula (I) (See formula I) wherein X is -CHOH- or -CO-; R1 and R2 are hydrogen or substituted oxycarbonyl; R3 is substituted oxycarbonyl; R4 is hydroxyl, lower alkoxy, optionally substituted piperazinyl or the like; R5 is a R-group side chain of an .alpha.-amino acid optionally protected by a protective group, R6 is hydroxyl, lower alkoxy or the like; m is 0 or 1; and n is an integer of 2 to 6; or a pharmaceutically acceptable salt thereof. The present invention further provides a production process and use thereof.
La présente invention concerne des dérivés peptidiques représentés par la formule générale (I), ainsi que les sels pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des procédés permettant de préparer les dérivés ou leurs sels, ainsi que l'utilisation de ceux-ci. Dans la formule générale (I), X représente -CHOH- ou -CO-; R<1> et R<2 >représentent, chacun, hydrogène ou oxycarbonyl substitué; R<3> représente oxycarbonyl substitué; R<4> représente hydroxyle, alcoxy inférieur, ou autres éléments analogues; m représente 0 ou 1; et n représente un entier relatif compris entre 2 et 6.
Asao Tetsuji
Suda Yoshimitsu
Yamamoto Kenji
Kyushu University National University Corporation
Marks & Clerk
Taiho Pharmaceutical Co. Ltd.
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