Peptide derivatives and use thereof as substrates for...

Details Peptide derivatives and use thereof as substrates for... Peptide derivatives and use thereof as substrates for...

C - Chemistry, Metallurgy

07

K

530/5.04, 150/15

C07K 5/04 (2006.01) C07K 5/09 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C12Q 1/44 (2006.01)

Patent

CA 1253998

ABSTRACT Peptide derivatives of formula Image wherein R1 represents a substituted amino goup which is capable of being split orf enzymatically with formation of a colored or fluorescent compound R1 - H. The said peptide derivatives are used for quantitatively assaying the enzyme C1-esterase. The assaying is carried out by reacting a medium which contains C1-esterase or in which the latter is formed or consumed with a peptide derivative as derined above and measuring photometrically, spectrophotometrically, fluor- escence-spectrophotometrically or electrochemically the quantity of split product R1 - H released per time unit by the catalytic hydrolytic action of the said enzyme on the peptide derivative.

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