Peptide derivatives for the treatment and prevention of...

C - Chemistry – Metallurgy – 12 – P

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530/7.06, 195/12

C12P 21/02 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1335662

Peptide derivatives of the formula: Image wherein R1 is hydrogen or an acyl group; R2 is hydroxy and R3 is carboxy or protected carboxy, or R2 and R3 are linked together to represent a group of the formula : Image ; R4 is hydroxy or protected hydroxy; R5 is hydroxy or protected hydroxy; R6 is hydroxy, protected hydroxy or lower alkoxy; and ? is a single bond or a double bond, and a pharmaceutically acceptable salt thereof. Also disclosed are processes for the preparation of the above peptide derivatives, pharmaceutical compositions containing them as well as the treatment and prevention of asthma using these derivatives. Also disclosed is a biologically pure culture of the microorganism Streptomyces violaceoniger No. 9326 (FERM BP-1667). This microorganism can be used to produce the above peptide derivatives.

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