Peptide derivatives, their production and use

Details Peptide derivatives, their production and use Peptide derivatives, their production and use

C - Chemistry, Metallurgy

07

K

530/7.16

C07K 7/06 (2006.01) C07K 7/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1292841

Abstract of the Disclosure A peptide derivative of the general formula Image wherein R1 is a hydrogen atom, a C1-18 alkyl group or a substituted or unsubstituted phenyl C1-3 alkyl group; A is an amino or N-C1-6 alkylamino acid residue; B is a hydroxyl group, a substituted or unsubstituted amino group, or an amino acid or an amide thereof, or a physiologically acceptable salt thereof, can be advantageously used for the treatment and/or prevention of a disease including, among others, senile dementia (A1zheimer's dementia), cerebrovascular dementia, Alzheimer's disease, Pick's disease, Huntington's chorea, Creutzfeldt-Jakob disease, Parkinson's disease, and dementia due to spinocerebellar degeneration.

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