C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2617222
Disclosed is a peptide which is derived from a prostate-related protein, is capable of binding to an HLA-A3 super-type allele molecule and is recognized by cellular immune response and/or humoral immune response. The peptide can realize a cancer vaccine therapy for a prostate cancer patient who is positive for an HLA-A3 super-type allele molecule, and can contribute to the treatment of a prostate cancer patient who is negative for an HLA-A2 or HLA-A24 molecule for which a cancer vaccine candidate peptide has been already identified.
La présente invention concerne un peptide dérivé d~une protéine de la prostate, capable d~assurer la liaison d~une molécule allélique de super-type HLA-A3 et reconnu par une réponse immunitaire cellulaire et/ou une réponse immunitaire humorale. Le peptide peut être utilisé dans le cadre d~une thérapie de vaccin anticancéreux pour des patients souffrant d~un cancer de la prostate et positifs à une molécule allélique de super-type HLA-A3. Il peut contribuer au traitement de patients souffrant d~un cancer de la prostate et négatifs à une molécule HLA-A2 ou HLA-A24, pour lesquels un peptide vaccin anticancéreux potentiel a déjà été identifié.
Harada Mamoru
Itoh Kyogo
Noguchi Masanori
Green Peptide Co. Ltd.
Kirby Eades Gale Baker
LandOfFree
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