Peptide determinant associated with immunity

Details Peptide determinant associated with immunity Peptide determinant associated with immunity

C - Chemistry, Metallurgy

07

K

167/129, 530/13,

C07K 7/08 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340012

Novel peptides are provided involving sequences from proteins or interest which include a motif comprising a charged amino acid, followed by two hydrophobic amino acids, followed in the next or succeeding position by a polar amino acid, where the charged or polar amino acid may be substituted by glycine. Peptides having the motif are found to be stimulatory to T-cells and allow for modulation of immune response, as illustrated by tolerizing the host to neurological proteins.

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