Peptide epitopes common to antigens of the same multigene...

Details Peptide epitopes common to antigens of the same multigene... Peptide epitopes common to antigens of the same multigene...

G - Physics

01

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G01N 33/68 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2480696

The invention relates to the production of peptide epitopes common to a plurality of antigens of the same multigene family, said epitopes containing at least one common pentapeptide sequence preceded by three amino acids at the N-terminal end and optionally followed by one or two amino acids at the C-terminal end. The invention also relates to polynucleotides coding for said epitopes. Said peptides and polynucleotides can be especially used in anti-tumour immunotherapy.

L'invention est relative à l'obtention d'épitopes peptidiques communs à plusieurs antigènes d'une même famille multigénique, ces épitopes possédant au moins une séquence pentapeptidique commune précédée par 3 acides aminés à l'extrémité N-terminale, et éventuellement suivie par 1 ou 2 acides aminés à l'extrémité C-terminale. L'invention concerne également des polynucléotides codant pour ces épitopes. Lesdits peptides et polynucléotides sont utilisables notamment en immunothérapie anti-tumorale.

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